Intergenerational neural mediators of early-life anxious temperament.
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ABSTRACT:
SUBMITTER: Fox AS
PROVIDER: S-EPMC4517228 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Intergenerational neural mediators of early-life anxious temperament.
Fox Andrew S AS Oler Jonathan A JA Shackman Alexander J AJ Shelton Steven E SE Raveendran Muthuswamy M McKay D Reese DR Converse Alexander K AK Alexander Andrew A Davidson Richard J RJ Blangero John J Rogers Jeffrey J Kalin Ned H NH
Proceedings of the National Academy of Sciences of the United States of America 20150706 29
Understanding the heritability of neural systems linked to psychopathology is not sufficient to implicate them as intergenerational neural mediators. By closely examining how individual differences in neural phenotypes and psychopathology cosegregate as they fall through the family tree, we can identify the brain systems that underlie the parent-to-child transmission of psychopathology. Although research has identified genes and neural circuits that contribute to the risk of developing anxiety a ...[more]
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