Ontology highlight
ABSTRACT:
SUBMITTER: Pittenger C
PROVIDER: S-EPMC4517847 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Psychiatric annals 20150601 6
Established treatments for obsessive-compulsive disorder (OCD) are of benefit in approximately 3 of every 4 patients, but refractory disease remains distressingly common, and many treatment responders continue to experience considerable morbidity. This motivates a search for new insights into pathophysiology that may inform novel treatment strategies. Much recent work has focused on the neurotransmitter glutamate. Several lines of neurochemical and genetic evidence suggests that glutamate dysreg ...[more]