Ontology highlight
ABSTRACT:
SUBMITTER: Chow WY
PROVIDER: S-EPMC4518226 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Scientific reports 20150729
Collagens, the most abundant proteins in mammals, are defined by their triple-helical structures and distinctive Gly-Xaa-Yaa repeating sequence, where Xaa is often proline and Yaa, hydroxyproline (Hyp/O). It is known that hydroxyproline in the Yaa position stabilises the triple helix, and that lack of proline hydroxylation in vivo leads to dysfunctional collagen extracellular matrix assembly, due to a range of factors such as a change in hydration properties. In addition, we note that in model p ...[more]