Ontology highlight
ABSTRACT:
SUBMITTER: Cho E
PROVIDER: S-EPMC4518236 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cho Eunsil E Kim Dong-Hyun DH Hur Young-Na YN Whitcomb Daniel J DJ Regan Philip P Hong Jung-Hwa JH Kim Hanna H Ho Suh Young Y Cho Kwangwook K Park Mikyoung M
Scientific reports 20150729
Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking. CCNY is enriched in postsynaptic fractions from rat forebrain and is localized adjacent to postsynaptic sites in dendritic spines in rat hippocampal neurons. Usi ...[more]