Ontology highlight
ABSTRACT:
SUBMITTER: Valery C
PROVIDER: S-EPMC4518280 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Valéry Céline C Deville-Foillard Stéphanie S Lefebvre Christelle C Taberner Nuria N Legrand Pierre P Meneau Florian F Meriadec Cristelle C Delvaux Camille C Bizien Thomas T Kasotakis Emmanouil E Lopez-Iglesias Carmen C Gall Andrew A Bressanelli Stéphane S Le Du Marie-Hélène MH Paternostre Maïté M Artzner Franck F
Nature communications 20150720
External stimuli are powerful tools that naturally control protein assemblies and functions. For example, during viral entry and exit changes in pH are known to trigger large protein conformational changes. However, the molecular features stabilizing the higher pH structures remain unclear. Here we elucidate the conformational change of a self-assembling peptide that forms either small or large nanotubes dependent on the pH. The sub-angstrom high-pH peptide structure reveals a globular conformat ...[more]