Ontology highlight
ABSTRACT:
SUBMITTER: Shu NS
PROVIDER: S-EPMC4518304 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150721
The pH-low insertion peptide (pHLIP) binds to a membrane at pH 7.4 unstructured but folds across the bilayer as a transmembrane helix at pH∼6. Despite their promising applications as imaging probes and drug carriers that target cancer cells for cytoplasmic cargo delivery, the mechanism of pH modulation on pHLIP-membrane interactions has not been completely understood. Here, we show the first study on membrane-associated pHLIP using solid-state NMR spectroscopy. Data on residue-specific conformat ...[more]