Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.
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ABSTRACT:
SUBMITTER: Williams RM
PROVIDER: S-EPMC4518714 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Mesoscale nanoparticles selectively target the renal proximal tubule epithelium.
Williams Ryan M RM Shah Janki J Ng Brandon D BD Minton Denise R DR Gudas Lorraine J LJ Park Christopher Y CY Heller Daniel A DA
Nano letters 20150326 4
We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively in renal proximal tubules and up to 7 times more efficiently in the kidney than other organs. Although nanoparticles typically localize in the liver and spleen, modulating their size and opsonization potential allowed for stable targeting of the kidneys through a new proposed uptake mechanism. Applying this kidney targeting strategy, we anticipate use in the treatment of renal dis ...[more]
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