Ontology highlight
ABSTRACT:
SUBMITTER: Sierra-Mercado D
PROVIDER: S-EPMC4518729 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Sierra-Mercado Demetrio D McAllister Lauren M LM Lee Christopher C H CC Milad Mohammed R MR Eskandar Emad N EN Whalen Michael J MJ
Brain research 20150223
Post-traumatic stress disorder (PTSD) is characterized in part by impaired extinction of conditioned fear. Traumatic brain injury (TBI) is thought to be a risk factor for development of PTSD. We tested the hypothesis that controlled cortical impact (CCI) would impair extinction of fear learned by Pavlovian conditioning, in mice. To mimic the scenarios in which TBI occurs prior to or after exposure to an aversive event, severe CCI was delivered to the left parietal cortex at one of two time point ...[more]