Ontology highlight
ABSTRACT:
SUBMITTER: Chmatal L
PROVIDER: S-EPMC4519087 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Chmátal Lukáš L Yang Karren K Schultz Richard M RM Lampson Michael A MA
Current biology : CB 20150709 14
To ensure accurate chromosome segregation in cell division, erroneous kinetochore-microtubule (MT) attachments are recognized and destabilized . Improper attachments typically lack tension between kinetochores and are positioned off-center on the spindle. Low tension is a widely accepted mechanism for recognizing errors , but whether chromosome position regulates MT attachments has been difficult to test. We exploited a meiotic system in which kinetochores attached to opposite spindle poles diff ...[more]