Motor Sequence Learning and Consolidation in Unilateral De Novo Patients with Parkinson's Disease.

ABSTRACT: Previous research investigating motor sequence learning (MSL) and consolidation in patients with Parkinson's disease (PD) has predominantly included heterogeneous participant samples with early and advanced disease stages; thus, little is known about the onset of potential behavioral impairments. We employed a multisession MSL paradigm to investigate whether behavioral deficits in learning and consolidation appear immediately after or prior to the detection of clinical symptoms in the tested (left) hand. Specifically, our patient sample was limited to recently diagnosed patients with pure unilateral PD. The left hand symptomatic (LH-S) patients provided an assessment of performance following the onset of clinical symptoms in the tested hand. Conversely, right hand affected (left hand asymp

SUBMITTER: Dan X 

PROVIDER: S-EPMC4519305 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature