Ontology highlight
ABSTRACT:
SUBMITTER: Gimenez-Dejoz J
PROVIDER: S-EPMC4519324 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Giménez-Dejoz Joan J Kolář Michal H MH Ruiz Francesc X FX Crespo Isidro I Cousido-Siah Alexandra A Podjarny Alberto A Barski Oleg A OA Fanfrlík Jindřich J Parés Xavier X Farrés Jaume J Porté Sergio S
PloS one 20150729 7
Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well characterized enzyme with high retinaldehyde reductase activity, involved in the development of several cancer types, the enzymatic activity and physiological role of AKR1B15 are still poorly known. Here, the purified recombinant enzyme has been subjected to substrate specificity characterization, kinetic analysis and inhibitor screening, combi ...[more]