Ontology highlight
ABSTRACT:
SUBMITTER: Stylianopoulos T
PROVIDER: S-EPMC4519365 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Stylianopoulos Triantafyllos T Economides Eva-Athena EA Baish James W JW Fukumura Dai D Jain Rakesh K RK
Annals of biomedical engineering 20150211 9
Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable preferential delivery to tumor tissue. However, the size-dependency of the EPR, the limited penetration of nanoparticles into the tumor as well as the rapid binding of the particles or the released cytotoxic agents to cancer cells and stromal components inhibit the uniform distri ...[more]