SK channels and ventricular arrhythmias in heart failure.
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ABSTRACT:
SUBMITTER: Chang PC
PROVIDER: S-EPMC4519433 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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SK channels and ventricular arrhythmias in heart failure.
Chang Po-Cheng PC Chen Peng-Sheng PS
Trends in cardiovascular medicine 20150129 6
Small-conductance Ca(2+)-activated K(+) (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca(2+). The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is ...[more]
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