Ontology highlight
ABSTRACT:
SUBMITTER: Ai J
PROVIDER: S-EPMC4520163 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Ai Jun J Nie Jing J He Jiangbo J Guo Qin Q Li Mei M Lei Ying Y Liu Youhua Y Zhou Zhanmei Z Zhu Fengxin F Liang Min M Cheng Yongxian Y Hou Fan Fan FF
Journal of the American Society of Nephrology : JASN 20141112 8
TGF-β1, via Smad-dependent or Smad-independent signaling, has a central role in the pathogenesis of renal fibrosis. This pathway has been recognized as a potential target for antifibrotic therapy. Here, we identified GQ5, a small molecular phenolic compound isolated from the dried resin of Toxicodendron vernicifluum, as a potent and selective inhibitor of TGF-β1-induced Smad3 phosphorylation. In TGF-β1-stimulated renal tubular epithelial cells and interstitial fibroblast cells, GQ5 inhibited the ...[more]