Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential.

ABSTRACT:

Purpose

To investigate the feasibility and potential clinical benefit of linear energy transfer (LET) guided plan optimization in intensity modulated proton therapy (IMPT).

Methods and materials

A multicriteria optimization (MCO) module was used to generate a series of Pareto-optimal IMPT base plans (BPs), corresponding to defined objectives, for 5 patients with head-and-neck cancer and 2 with pancreatic cancer. A Monte Carlo platform was used to calculate dose and LET distributions for each BP. A custom-designed MCO navigation module allowed the user to interpolate between BPs to produce deliverable Pareto-optimal solutions. Differences among the BPs were evaluated for each patient, based on dose-volume and LET-volume histograms and 3-dimensional distributions. An LET-based

SUBMITTER: Giantsoudi D 

PROVIDER: S-EPMC4520412 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature