Copper at the Fungal Pathogen-Host Axis.
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ABSTRACT:
SUBMITTER: Garcia-Santamarina S
PROVIDER: S-EPMC4521015 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Copper at the Fungal Pathogen-Host Axis.
García-Santamarina Sarela S Thiele Dennis J DJ
The Journal of biological chemistry 20150608 31
Fungal infections are responsible for millions of human deaths annually. Copper, an essential but toxic trace element, plays an important role at the host-pathogen axis during infection. In this review, we describe how the host uses either Cu compartmentalization within innate immune cells or Cu sequestration in other infected host niches such as in the brain to combat fungal infections. We explore Cu toxicity mechanisms and the Cu homeostasis machinery that fungal pathogens bring into play to s ...[more]
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