Ontology highlight
ABSTRACT:
SUBMITTER: Groothuizen FS
PROVIDER: S-EPMC4521584 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Groothuizen Flora S FS Winkler Ines I Cristóvão Michele M Fish Alexander A Winterwerp Herrie H K HH Reumer Annet A Marx Andreas D AD Hermans Nicolaas N Nicholls Robert A RA Murshudov Garib N GN Lebbink Joyce H G JH Friedhoff Peter P Sixma Titia K TK
eLife 20150711
To avoid mutations in the genome, DNA replication is generally followed by DNA mismatch repair (MMR). MMR starts when a MutS homolog recognizes a mismatch and undergoes an ATP-dependent transformation to an elusive sliding clamp state. How this transient state promotes MutL homolog recruitment and activation of repair is unclear. Here we present a crystal structure of the MutS/MutL complex using a site-specifically crosslinked complex and examine how large conformational changes lead to activati ...[more]