JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade.

ABSTRACT: Organogenesis is controlled by gene networks activated by upstream selector genes. During development the gene network is activated stepwise, with a sequential deployment of successive transcription factors and signalling molecules that modify the interaction of the elements of the network as the organ forms. Very little is known about the steps leading from the early specification of the cells that form the organ primordium to the moment when a robust gene network is in place. Here we study in detail how a Hox protein induces during early embryogenesis a simple organogenetic cascade that matures into a complex gene network through the activation of feedback and feed forward interaction loops. To address how the network organization changes during development and how the target genes integ

SUBMITTER: Pinto PB 

PROVIDER: S-EPMC4521708 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature