Dataset Information

Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.

ABSTRACT:

Purpose

To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma.

Methods

Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from images in three orthogonal planes. The centroid of the mapped area was calculated to approximate tumor origin, and the location and cumulative tumor burden were analyzed in relation to mutation type (germline vs. somatic), tumor area, and patient age at diagnosis. Location of small tumors undetected by MRI was approximated with fundoscopic images.

Results

Mapping was successful for 129 tumors in 91 eyes from 67 patients (39 bilateral, 43 germline mutation). Cumulative tumor burden was highest within the macula and posterior pole and was asymmetrically higher within the inferonasal periphery. Tumor incidence was lowest in the superotemporal periphery. Tumor location varied with age at diagnosis in a complex pattern. Tumor location was concentrated in the macula and superonasal periphery in patients <5.6 months, in the inferotemporal quadrant of the posterior pole in patients 5.6-8.8 months, in the inferonasal quadrant in patients 8.8-13.2 months, and in the nasal and superotemporal periphery in patients >13.2 months. The distribution of MRI-invisible tumors was consistent with the asymmetry of mapped tumors.

Conclusions

MRI-based mapping revealed a previously unrecognized pattern of retinoblastoma localization that evolves with age at diagnosis. The structured spatiotemporal distribution of tumors may provide valuable clues about cellular or molecular events associated with tumorigenesis in the developing retina.

SUBMITTER: King BA

PROVIDER: S-EPMC4521796 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.

King Benjamin A BA Parra Carlos C Li Yimei Y Helton Kathleen J KJ Qaddoumi Ibrahim I Wilson Matthew W MW Ogg Robert J RJ

PloS one 20150731 7

<h4>Purpose</h4>To accurately map the retinal area covered by tumor in a prospectively enrolled cohort of children diagnosed with retinoblastoma.<h4>Methods</h4>Orbital MRI in 106 consecutive retinoblastoma patients (44 bilateral) was analyzed. For MRI-visible tumors, the polar angle and angle of eccentricity of points defining tumor perimeter on the retina were determined by triangulation from images in three orthogonal planes. The centroid of the mapped area was calculated to approximate tumor ...[more]

PMID: 26230335

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Project description:BackgroundPrior ecologic studies suggest that UV exposure through sunlight to the retina might contribute to increased retinoblastoma incidence.AimsOur study objectives were (1) to examine the relationship between exposure to sunlight during postnatal retinal development (prior to diagnosis of sporadic disease) and the risk of retinoblastoma, and (2) to examine the relationship between sun exposure during postnatal retinal development, and the extent of disease among children with unilateral and bilateral retinoblastoma.Methods and resultsWe interviewed 511 mothers in the EpiRbMx case-control study about their child's exposure to sunlight during postnatal retinal cell division by examining three time periods prior to Rtb diagnosis coinciding with developmental stages in which outdoor activities vary. Weekly sun exposure was compared by age period, between unilateral (n = 259), bilateral (n = 120), and control (n = 132) children, accounting for two factors affecting UV exposure: residential elevation and reported use of coverings to shield eyes. For cases, association between sunlight exposure and clinical stage was examined by laterality at each age period. After adjusting for maternal education and elevation, sun exposure was lower in cases than controls in all three age periods especially during the first 6 months, and in children 12-23 months whose mothers did not cover their eyes when outdoors. In children diagnosed after 12 months of age, sun exposure during the second year of life (age 12-23 months) appeared inversely correlated (r = -0.25) with more advanced intraocular disease in bilateral Rtb children after adjusting for maternal education, residential elevation, and age of diagnosis (p < .09) consistent with effects of Vitamin D exposure on intraocular spread in earlier transgenic murine models of retinoblastoma, and suggesting potential chemopreventive strategies.ConclusionSun exposure in early childhood is protective for retinoblastoma and may decrease degree of intraocular spread in children with bilateral Rtb.

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Dataset Information

Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.

Purpose

Methods

Results

Conclusions

Publications

Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma.

Similar Datasets

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