Ontology highlight
ABSTRACT:
SUBMITTER: Pizarro M
PROVIDER: S-EPMC4522413 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Pizarro Margarita M Solís Nancy N Quintero Pablo P Barrera Francisco F Cabrera Daniel D Rojas-de Santiago Pamela P Arab Juan P JP Padilla Oslando O Roa Juan C JC Moshage Han H Wree Alexander A Inzaugarat Eugenia E Feldstein Ariel E AE Fardella Carlos E CE Baudrand Rene R Riquelme Arnoldo A Arrese Marco M
Liver international : official journal of the International Association for the Study of the Liver 20150223 9
<h4>Background</h4>Therapeutic options to treat Non-alcoholic steatohepatitis (NASH) are limited. Mineralocorticoid receptor (MR) activation could play a role in hepatic fibrogenesis and its modulation could be beneficial for NASH.<h4>Aim</h4>To investigate whether eplerenone, a specific MR antagonist, ameliorates liver damage in experimental NASH.<h4>Methods</h4>C57bl6 mice were fed a choline-deficient and amino acid-defined (CDAA) diet for 22 weeks with or without eplerenone supplementation. S ...[more]