Structure-based functional annotation of hypothetical proteins from Candida dubliniensis: a quest for potential drug targets.

ABSTRACT: Candida dubliniensis is an emerging pathogenic yeast in humans and infections are usually restricted to mucosal parts of the body. However, its presence in specimens of immunocompromised individuals, especially in HIV-positive patients, is of major medical concern. There is a large fraction of genomes of C. dubliniensis in the database which are uncharacterized for their biochemical, biophysical, and/or cellular functions, and are identified as hypothetical proteins (HPs). Function annotation of Candida genome is, therefore, essentially required to facilitate the understanding of mechanisms of pathogenesis and biochemical pathways important for selecting novel therapeutic target. Here, we carried out an extensive analysis to explain the functional properties of genome, using available prot

SUBMITTER: Kumar K 

PROVIDER: S-EPMC4522726 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature