Ontology highlight
ABSTRACT:
SUBMITTER: Luo S
PROVIDER: S-EPMC4522777 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Luo Sulan S Zhangsun Dongting D Harvey Peta J PJ Kaas Quentin Q Wu Yong Y Zhu Xiaopeng X Hu Yuanyan Y Li Xiaodan X Tsetlin Victor I VI Christensen Sean S Romero Haylie K HK McIntyre Melissa M Dowell Cheryl C Baxter James C JC Elmslie Keith S KS Craik David J DJ McIntosh J Michael JM
Proceedings of the National Academy of Sciences of the United States of America 20150713 30
We identified a previously unidentified conotoxin gene from Conus generalis whose precursor signal sequence has high similarity to the O1-gene conotoxin superfamily. The predicted mature peptide, αO-conotoxin GeXIVA (GeXIVA), has four Cys residues, and its three disulfide isomers were synthesized. Previously pharmacologically characterized O1-superfamily peptides, exemplified by the US Food and Drug Administration-approved pain medication, ziconotide, contain six Cys residues and are calcium, so ...[more]