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RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.


ABSTRACT: RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain.We performed a computerized search of the electronic medical record of our institution for mCRC cases genotyped for RAS or PIK3CA mutations from 2008 to 2012. Cases were reviewed for patient characteristics, survival, and site-specific metastasis.Among the 918 patients identified, 477 cases were RAS wild type, and 441 cases had a RAS mutation (394 at KRAS exon 2, 29 at KRAS exon 3 or 4, and 18 in NRAS). RAS mutation was significantly associated with shorter median overall survival (OS) and on multivariate analysis independently predicted worse OS (HR, 1.6; P

SUBMITTER: Yaeger R 

PROVIDER: S-EPMC4523078 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.

Yaeger Rona R   Cowell Elizabeth E   Chou Joanne F JF   Gewirtz Alexandra N AN   Borsu Laetitia L   Vakiani Efsevia E   Solit David B DB   Rosen Neal N   Capanu Marinela M   Ladanyi Marc M   Kemeny Nancy N  

Cancer 20141209 8


<h4>Background</h4>RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain.<h4>Methods</h4>We performed a computerized search of the electronic medical record of our institution for mCRC cases genotyped for RAS or PIK3CA mutations from 2008 to 2012. Cases were revi  ...[more]

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