Ontology highlight
ABSTRACT:
SUBMITTER: Yaeger R
PROVIDER: S-EPMC4523078 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Yaeger Rona R Cowell Elizabeth E Chou Joanne F JF Gewirtz Alexandra N AN Borsu Laetitia L Vakiani Efsevia E Solit David B DB Rosen Neal N Capanu Marinela M Ladanyi Marc M Kemeny Nancy N
Cancer 20141209 8
<h4>Background</h4>RAS and PIK3CA mutations in metastatic colorectal cancer (mCRC) have been associated with worse survival. We sought to evaluate the impact of RAS and PIK3CA mutations on cumulative incidence of metastasis to potentially curable sites of liver and lung and other sites such as bone and brain.<h4>Methods</h4>We performed a computerized search of the electronic medical record of our institution for mCRC cases genotyped for RAS or PIK3CA mutations from 2008 to 2012. Cases were revi ...[more]