Whole genomes redefine the mutational landscape of pancreatic cancer.
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ABSTRACT:
SUBMITTER: Waddell N
PROVIDER: S-EPMC4523082 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Publications
Whole genomes redefine the mutational landscape of pancreatic cancer.
Waddell Nicola N Pajic Marina M Patch Ann-Marie AM Chang David K DK Kassahn Karin S KS Bailey Peter P Johns Amber L AL Miller David D Nones Katia K Quek Kelly K Quinn Michael C J MC Robertson Alan J AJ Fadlullah Muhammad Z H MZ Bruxner Tim J C TJ Christ Angelika N AN Harliwong Ivon I Idrisoglu Senel S Manning Suzanne S Nourse Craig C Nourbakhsh Ehsan E Wani Shivangi S Wilson Peter J PJ Markham Emma E Cloonan Nicole N Anderson Matthew J MJ Fink J Lynn JL Holmes Oliver O Kazakoff Stephen H SH Leonard Conrad C Newell Felicity F Poudel Barsha B Song Sarah S Taylor Darrin D Waddell Nick N Wood Scott S Xu Qinying Q Wu Jianmin J Pinese Mark M Cowley Mark J MJ Lee Hong C HC Jones Marc D MD Nagrial Adnan M AM Humphris Jeremy J Chantrill Lorraine A LA Chin Venessa V Steinmann Angela M AM Mawson Amanda A Humphrey Emily S ES Colvin Emily K EK Chou Angela A Scarlett Christopher J CJ Pinho Andreia V AV Giry-Laterriere Marc M Rooman Ilse I Samra Jaswinder S JS Kench James G JG Pettitt Jessica A JA Merrett Neil D ND Toon Christopher C Epari Krishna K Nguyen Nam Q NQ Barbour Andrew A Zeps Nikolajs N Jamieson Nigel B NB Graham Janet S JS Niclou Simone P SP Bjerkvig Rolf R Grützmann Robert R Aust Daniela D Hruban Ralph H RH Maitra Anirban A Iacobuzio-Donahue Christine A CA Wolfgang Christopher L CL Morgan Richard A RA Lawlor Rita T RT Corbo Vincenzo V Bassi Claudio C Falconi Massimo M Zamboni Giuseppe G Tortora Giampaolo G Tempero Margaret A MA Gill Anthony J AJ Eshleman James R JR Pilarsky Christian C Scarpa Aldo A Musgrove Elizabeth A EA Pearson John V JV Biankin Andrew V AV Grimmond Sean M SM
Nature 20150201 7540
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be important in pancreatic cancer (TP53, SMAD4, CDKN2A, ARID1A and ROBO2) and new candidate drivers of pancreatic carcinogenesis (KDM6A and PREX2). Patterns of structural variation (var ...[more]
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