Determinants of the rate of protein sequence evolution.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC4523088 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Determinants of the rate of protein sequence evolution.
Zhang Jianzhi J Yang Jian-Rong JR
Nature reviews. Genetics 20150609 7
The rate and mechanism of protein sequence evolution have been central questions in evolutionary biology since the 1960s. Although the rate of protein sequence evolution depends primarily on the level of functional constraint, exactly what determines functional constraint has remained unclear. The increasing availability of genomic data has enabled much needed empirical examinations on the nature of functional constraint. These studies found that the evolutionary rate of a protein is predominant ...[more]
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