Ppm1b negatively regulates necroptosis through dephosphorylating Rip3.
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ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC4523090 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3.
Chen Wanze W Wu Jianfeng J Li Lisheng L Zhang Zhengmao Z Ren Junming J Liang Yaoji Y Chen Fenfang F Yang Chao C Zhou Zhenru Z Su Sheng Sean SS Zheng Xinru X Zhang Zhirong Z Zhong Chuan-Qi CQ Wan Haoqiang H Xiao Mu M Lin Xia X Feng Xin-Hua XH Han Jiahuai J
Nature cell biology 20150309 4
The auto-phosphorylation of murine receptor-interacting protein 3 (Rip3) on Thr 231 and Ser 232 in the necrosome is required to trigger necroptosis. However, how Rip3 phosphorylation is regulated is still largely unknown. Here we identified protein phosphatase 1B (Ppm1b) as a Rip3 phosphatase and found that Ppm1b restricts necroptosis in two settings: spontaneous necroptosis caused by Rip3 auto-phosphorylation in resting cells, and tumour necrosis factor-α (TNF)-induced necroptosis in cultured c ...[more]
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