Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4523094 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Huang Jie J Liu Ying Y Oltean Alina A Beebe David C DC
Developmental biology 20150316 1
Previous studies of mouse embryos concluded that after the optic vesicle evaginates from the ventral forebrain and contacts the surface ectoderm, signals from the ectoderm specify the distal region of the optic vesicle to become retina and signals from the optic vesicle induce the lens. Germline deletion of Bmp4 resulted in failure of lens formation. We performed conditional deletion of Bmp4 from the optic vesicle to test the function of Bmp4 in murine eye development. The optic vesicle evaginat ...[more]