Ontology highlight
ABSTRACT:
SUBMITTER: Hiroshima Y
PROVIDER: S-EPMC4523197 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hiroshima Yukihiko Y Zhao Ming M Zhang Yong Y Zhang Nan N Maawy Ali A Murakami Takashi T Mii Sumiyuki S Uehara Fuminari F Yamamoto Mako M Miwa Shinji S Yano Shuya S Momiyama Masashi M Mori Ryutaro R Matsuyama Ryusei R Chishima Takashi T Tanaka Kuniya K Ichikawa Yasushi Y Bouvet Michael M Endo Itaru I Hoffman Robert M RM
PloS one 20150803 8
A patient-derived nude-mouse model of soft-tissue sarcoma has been established and treated in the following groups: (1) untreated controls; (2) gemcitabine (GEM) (80 mg/kg, ip, weekly, 3 weeks); (3) Pazopanib (100 mg/kg, orally, daily, 3 weeks) and (4) Salmonella typhimurium A1-R (5 × 10(7) CFU/body, ip, weekly, 3 weeks). The sarcoma was resistant to GEM (p = 0.879). Pazopanib tended to reduce the tumor volume compared to the untreated mice, but there was no significant difference (p = 0.115). S ...[more]