Ontology highlight
ABSTRACT:
SUBMITTER: Yano S
PROVIDER: S-EPMC4523223 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Yano S S Hiroshima Y Y Maawy A A Kishimoto H H Suetsugu A A Miwa S S Toneri M M Yamamoto M M Katz M H G MH Fleming J B JB Urata Y Y Tazawa H H Kagawa S S Bouvet M M Fujiwara T T Hoffman R M RM
Cancer gene therapy 20150619 7
Precise fluorescence-guided surgery (FGS) for pancreatic cancer has the potential to greatly improve the outcome in this recalcitrant disease. To achieve this goal, we have used genetic reporters to color code cancer and stroma cells in a patient-derived orthotopic xenograft (PDOX) model. The telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 was used to label the cancer cells of a pancreatic cancer PDOX. The PDOX was previously grown in a red fluorescent protein ...[more]