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Identification of pathways for bipolar disorder: a meta-analysis.


ABSTRACT: IMPORTANCE:Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders. OBJECTIVE:To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS). DATA SOURCES:Four independent data sets with individual genome-wide data available in July 2011 along with all data sets contributed to the Psychiatric Genomics Consortium Bipolar Group by May 2012. A prior meta-analysis was used as a source for brain gene expression data. STUDY SELECTION:The 4 published GWAS were included in the initial sample. All independent BP data sets providing genome-wide data in the Psychiatric Genomics Consortium were included as a replication sample. DATA EXTRACTION AND SYNTHESIS:We identified 966 genes that contained 2 or more variants associated with BP at P

SUBMITTER: Nurnberger JI 

PROVIDER: S-EPMC4523227 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Identification of pathways for bipolar disorder: a meta-analysis.

Nurnberger John I JI   Koller Daniel L DL   Jung Jeesun J   Edenberg Howard J HJ   Foroud Tatiana T   Guella Ilaria I   Vawter Marquis P MP   Kelsoe John R JR  

JAMA psychiatry 20140601 6


<h4>Importance</h4>Genome-wide investigations provide systematic information regarding the neurobiology of psychiatric disorders.<h4>Objective</h4>To identify biological pathways that contribute to risk for bipolar disorder (BP) using genes with consistent evidence for association in multiple genome-wide association studies (GWAS).<h4>Data sources</h4>Four independent data sets with individual genome-wide data available in July 2011 along with all data sets contributed to the Psychiatric Genomic  ...[more]

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