Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan P
PROVIDER: S-EPMC4523390 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Narayanan Praveena P Chatterton Paul P Ikeda Akihiro A Ikeda Sakae S Corey David P DP Ervasti James M JM Perrin Benjamin J BJ
Nature communications 20150421
Auditory sensory hair cells depend on stereocilia with precisely regulated lengths to detect sound. Since stereocilia are primarily composed of crosslinked, parallel actin filaments, regulated actin dynamics are essential for controlling stereocilia length. Here we assessed stereocilia actin turnover by monitoring incorporation of inducibly expressed β-actin-GFP in adult mouse hair cells in vivo and by directly measuring β-actin-GFP turnover in explants. Stereocilia actin incorporation is remark ...[more]