Mitochondrial DNA: A disposable genome?
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ABSTRACT:
SUBMITTER: Shokolenko IN
PROVIDER: S-EPMC4523420 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Publications
Mitochondrial DNA: A disposable genome?
Shokolenko Inna N IN Alexeyev Mikhail F MF
Biochimica et biophysica acta 20150610 9
In mammalian cells, mitochondria are the only organelles besides the nucleus that house genomic DNA. The mammalian mitochondrial genome is represented by prokaryotic-type, circular, highly compacted DNA molecules. Today, more than a half-century after their discovery, the biology of these small and redundant molecules remains much less understood than that of their nuclear counterparts. One peculiarity of the mitochondrial genome that emerged in recent years is its disposable nature, as evidence ...[more]
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