Ontology highlight
ABSTRACT:
SUBMITTER: Lin CH
PROVIDER: S-EPMC4523617 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Lin Chin-Hsien CH Li Hsun H Lee Yi-Nan YN Cheng Ying-Ju YJ Wu Ruey-Meei RM Chien Cheng-Ting CT
The Journal of cell biology 20150727 3
Constructing the dendritic arbor of neurons requires dynamic movements of Golgi outposts (GOPs), the prominent component in the dendritic secretory pathway. GOPs move toward dendritic ends (anterograde) or cell bodies (retrograde), whereas most of them remain stationary. Here, we show that Leucine-rich repeat kinase (Lrrk), the Drosophila melanogaster homologue of Parkinson's disease-associated Lrrk2, regulates GOP dynamics in dendrites. Lrrk localized at stationary GOPs in dendrites and suppres ...[more]