Ontology highlight
ABSTRACT:
SUBMITTER: Garre S
PROVIDER: S-EPMC4524338 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Garre Satish S Senevirathne Chamara C Pflum Mary Kay H MK
Bioorganic & medicinal chemistry 20140130 5
Kinase-catalyzed protein phosphorylation is an important post-translational modification that regulates a variety of cellular functions. Identification of the many substrates of a specific kinase is critical to fully characterize cell biology. Unfortunately, kinase-substrate interactions are often transient, which makes their identification challenging. Here, the transient kinase-substrate complex was stabilized by covalent crosslinking using γ-phosphate modified ATP analogs. Building upon prior ...[more]