Ontology highlight
ABSTRACT:
SUBMITTER: Murray AT
PROVIDER: S-EPMC4524416 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Murray Alexander T AT Dowley Myles J H MJ Pradaux-Caggiano Fabienne F Baldansuren Amgalanbaatar A Fielding Alistair J AJ Tuna Floriana F Hendon Christopher H CH Walsh Aron A Lloyd-Jones Guy C GC John Matthew P MP Carbery David R DR
Angewandte Chemie (International ed. in English) 20150618 31
The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical ...[more]