Ontology highlight
ABSTRACT:
SUBMITTER: Huang B
PROVIDER: S-EPMC4524707 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Huang Bin B Wang Yongkui Y Wang Wenhao W Chen Juan J Lai Pinglin P Liu Zhongyu Z Yan Bo B Xu Song S Zhang Zhongmin Z Zeng Chun C Rong Limin L Liu Bin B Cai Daozhang D Jin Dadi D Bai Xiaochun X
PLoS genetics 20150804 8
The mechanistic target of rapamycin (mTOR) integrates both intracellular and extracellular signals to regulate cell growth and metabolism. However, the role of mTOR signaling in osteoblast differentiation and bone formation is undefined, and the underlying mechanisms have not been elucidated. Here, we report that activation of mTOR complex 1 (mTORC1) is required for preosteoblast proliferation; however, inactivation of mTORC1 is essential for their differentiation and maturation. Inhibition of m ...[more]