Unknown

Dataset Information

0

Association between Paraoxonase 1 (PON1) Polymorphisms and the Risk of Acute Coronary Syndrome in a North African Population.


ABSTRACT: The purpose of the present study was to investigate the distribution of PON1 Q192R and L55M polymorphisms and activities in a North African population and to determine their association with cardiovascular complications. The prevalence of the QQ, QR, RR, LL, LM, and MM genotypes in the study population was 55.4%, 34.09%, 9.83%, 41.97%, 48.20%, and 9.83% respectively. The Q, R, L, and M alleles had a gene frequency of 0.755, 0.245, 0.67, and 0.33, respectively. The PON1 192 RR genotype was significantly more prevalent among ACS patients than among healthy subjects. There was a 4.33-fold increase in the risk of ACS in subjects presenting the PON1 192 RR genotype compared to those with the QQ genotype (OR=4.33; 95% CI=1.27-17.7). There was a significantly different distribution of PON1 L55M in the ACS patient groups (UA, STEMI, NSTEMI). Moreover, individuals presenting the PON1 55MM genotype present a higher risk for ACS than those with LL genotype (OR=3.69; 95% CI=1.61-11.80). Paraoxonase activities were significantly lower in coronary patients than in healthy subjects. The decrease in PON1 activity was inversely correlated with the number of concomitant risk factors for CVD (r=0.57, p<0.0001). The results of the present study suggested that the PON1 R and M alleles may play a role in the pathogenesis of cardiac ischemia in our North African population and that a decrease in PON1 activity may be a valuable marker for monitoring the development of the atherosclerosis process and the associated cardiovascular complications.

SUBMITTER: Bounafaa A 

PROVIDER: S-EPMC4524730 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association between Paraoxonase 1 (PON1) Polymorphisms and the Risk of Acute Coronary Syndrome in a North African Population.

Bounafaa Abdelghani A   Berrougui Hicham H   Ghalim Noreddine N   Nasser Boubker B   Bagri Abdallah A   Moujahid Abderrahmane A   Ikhlef Souad S   Camponova Pamela P   Yamoul Najoua N   Simo Olivier Kamtchueng OK   Essamadi Abdelkhalid A   Khalil Abdelouahed A  

PloS one 20150804 8


The purpose of the present study was to investigate the distribution of PON1 Q192R and L55M polymorphisms and activities in a North African population and to determine their association with cardiovascular complications. The prevalence of the QQ, QR, RR, LL, LM, and MM genotypes in the study population was 55.4%, 34.09%, 9.83%, 41.97%, 48.20%, and 9.83% respectively. The Q, R, L, and M alleles had a gene frequency of 0.755, 0.245, 0.67, and 0.33, respectively. The PON1 192 RR genotype was signif  ...[more]

Similar Datasets

| S-EPMC3689331 | biostudies-literature
| S-EPMC3101202 | biostudies-literature
| S-EPMC3102863 | biostudies-literature
| S-EPMC3047195 | biostudies-literature
| S-EPMC1226129 | biostudies-literature
| S-EPMC7211330 | biostudies-literature
| S-EPMC3147178 | biostudies-literature
| S-EPMC2936881 | biostudies-literature
| S-EPMC6817089 | biostudies-literature
| S-EPMC5214702 | biostudies-literature