Ontology highlight
ABSTRACT:
SUBMITTER: Cho MH
PROVIDER: S-EPMC4525167 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Cho Min-Hyung MH Park Ji-Hye JH Choi Hee-Joo HJ Park Mi-Kyung MK Won Hee-Young HY Park Yeon-Ji YJ Lee Chang Hoon CH Oh Seung-Hyun SH Song Young-Soo YS Kim Hyun Sung HS Oh Young-Ha YH Lee Jeong-Yeon JY Kong Gu G
Nature communications 20150722
DOT1L has emerged as an anticancer target for MLL-associated leukaemias; however, its functional role in solid tumours is largely unknown. Here we identify that DOT1L cooperates with c-Myc and p300 acetyltransferase to epigenetically activate epithelial-mesenchymal transition (EMT) regulators in breast cancer progression. DOT1L recognizes SNAIL, ZEB1 and ZEB2 promoters via interacting with the c-Myc-p300 complex and facilitates lysine-79 methylation and acetylation towards histone H3, leading to ...[more]