Ontology highlight
ABSTRACT:
SUBMITTER: Gaines WA
PROVIDER: S-EPMC4525180 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gaines William A WA Godin Stephen K SK Kabbinavar Faiz F FF Rao Timsi T VanDemark Andrew P AP Sung Patrick P Bernstein Kara A KA
Nature communications 20150728
The conserved budding yeast Rad51 paralogues, including Rad55, Rad57, Csm2 and Psy3 are indispensable for homologous recombination (HR)-mediated chromosome damage repair. Rad55 and Rad57 are associated in a heterodimer, while Csm2 and Psy3 form the Shu complex with Shu1 and Shu2. Here we show that Rad55 bridges an interaction between Csm2 with Rad51 and Rad52 and, using a fully reconstituted system, demonstrate that the Shu complex synergizes with Rad55-Rad57 and Rad52 to promote nucleation of R ...[more]