Ontology highlight
ABSTRACT:
SUBMITTER: Pencik J
PROVIDER: S-EPMC4525303 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature communications 20150722
Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient PCa mouse model accelerates cancer progression leading to metastasis. Mechanistically, we identify p19(ARF) as a direct Stat3 target. Loss of Stat3 signalling disrupts the ARF-Mdm2-p53 tumour suppress ...[more]