Ontology highlight
ABSTRACT:
SUBMITTER: Kavanaugh G
PROVIDER: S-EPMC4525316 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Kavanaugh Gina G Zhao Runxiang R Guo Yan Y Mohni Kareem N KN Glick Gloria G Lacy Monica E ME Hutson M Shane MS Ascano Manuel M Cortez David D
Molecular and cellular biology 20150622 17
Accurate replication of DNA is imperative for the maintenance of genomic integrity. We identified Enhancer of Rudimentary Homolog (ERH) using a whole-genome RNA interference (RNAi) screen to discover novel proteins that function in the replication stress response. Here we report that ERH is important for DNA replication and recovery from replication stress. ATR pathway activity is diminished in ERH-deficient cells. The reduction in ATR signaling corresponds to a decrease in the expression of mul ...[more]