Dataset Information

Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women.

ABSTRACT:

Objective

To assess change in overactive bladder (OAB) symptoms up to 5 years after surgery and to identify associated predictors of change from baseline.

Methods

This is a secondary analysis of data from three multicenter urinary incontinence (UI) surgical trials of women with stress-predominant mixed UI assigned to Burch colposuspension, autologous fascial sling, or retropubic or transobturator midurethral slings. The primary outcome was improvement of 70% or greater from baseline in symptoms measured by the Urinary Distress Inventory-Irritative subscale. Surgical groups were compared within respective trials. Generalized linear models were fit using 1-year and up to 5-year data.

Results

Significant improvements in Urinary Distress Inventory-Irritative scores were reported by each surgical group 1 year after surgery (P<.001). Most women (50-71%) reported improvement in OAB symptoms. Improvements were similar between midurethral sling groups at 1 year (65.5% compared with 70.7%, P=.32; odds ratio [OR] 0.83, 95% confidence interval [CI] 0.57-1.20 for retropubic compared with transobturator sling) and throughout the 5-year follow-up period. More women reported OAB symptom improvement after Burch compared with pubovaginal sling (67.9% compared with 56.6%, P=.01; OR 1.59, 95% CI 1.10-2.31 for Burch compared with sling); this group difference at 1 year persisted throughout the 5-year follow-up. At 1-year, 50.0-64.3% of patients reported 70% greater improvement in UI. This proportion declined to 36.5-54.1% at 5 years (P<.001). Preoperative use of anticholinergics and urodynamic parameters was not predictive of OAB symptom change after surgery.

Conclusion

Most women with stress-predominant mixed UI experienced significant improvement in OAB symptoms after incontinence surgery although this initial improvement diminished over time. Obesity blunted symptom improvement.

Level of evidence

II.

SUBMITTER: Zyczynski HM

PROVIDER: S-EPMC4526119 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Publications

Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women.

Zyczynski Halina M HM Albo Michael E ME Goldman Howard B HB Wai Clifford Y CY Sirls Larry T LT Brubaker Linda L Norton Peggy P Varner R E RE Carmel Maude M Kim Hae-Young HY

Obstetrics and gynecology 20150801 2

<h4>Objective</h4>To assess change in overactive bladder (OAB) symptoms up to 5 years after surgery and to identify associated predictors of change from baseline.<h4>Methods</h4>This is a secondary analysis of data from three multicenter urinary incontinence (UI) surgical trials of women with stress-predominant mixed UI assigned to Burch colposuspension, autologous fascial sling, or retropubic or transobturator midurethral slings. The primary outcome was improvement of 70% or greater from baseli ...[more]

PMID: 26241434

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Dataset Information

Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women.

Objective

Methods

Results

Conclusion

Level of evidence

Publications

Change in Overactive Bladder Symptoms After Surgery for Stress Urinary Incontinence in Women.

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