Ontology highlight
ABSTRACT:
SUBMITTER: Wesener DA
PROVIDER: S-EPMC4526365 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Wesener Darryl A DA Wangkanont Kittikhun K McBride Ryan R Song Xuezheng X Kraft Matthew B MB Hodges Heather L HL Zarling Lucas C LC Splain Rebecca A RA Smith David F DF Cummings Richard D RD Paulson James C JC Forest Katrina T KT Kiessling Laura L LL
Nature structural & molecular biology 20150706 8
The glycans displayed on mammalian cells can differ markedly from those on microbes. Such differences could, in principle, be 'read' by carbohydrate-binding proteins, or lectins. We used glycan microarrays to show that human intelectin-1 (hIntL-1) does not bind known human glycan epitopes but does interact with multiple glycan epitopes found exclusively on microbes: β-linked D-galactofuranose (β-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3- ...[more]