HMG-CoA Reductase Inhibitors Bind to PPAR? to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
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ABSTRACT:
SUBMITTER: Roy A
PROVIDER: S-EPMC4526399 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
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HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Roy Avik A Jana Malabendu M Kundu Madhuchhanda M Corbett Grant T GT Rangaswamy Suresh B SB Mishra Rama K RK Luan Chi-Hao CH Gonzalez Frank J FJ Pahan Kalipada K
Cell metabolism 20150625 2
Neurotrophins are important for neuronal health and function. Here, statins, inhibitors of HMG-CoA reductase and cholesterol lowering drugs, were found to stimulate expression of neurotrophins in brain cells independent of the mevalonate pathway. Time-resolved fluorescence resonance energy transfer (FRET) analyses, computer-derived simulation, site-directed mutagenesis, thermal shift assay, and de novo binding followed by electrospray ionization tandem mass spectrometry (ESI-MS) demonstrates tha ...[more]
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