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Emerging Treatment Paradigms in Radiation Oncology.


ABSTRACT: Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune response, or protect normal tissues.

SUBMITTER: Le QT 

PROVIDER: S-EPMC4526434 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Emerging Treatment Paradigms in Radiation Oncology.

Le Quynh-Thu QT   Shirato Hiroki H   Giaccia Amato J AJ   Koong Albert C AC  

Clinical cancer research : an official journal of the American Association for Cancer Research 20150519 15


Rapid advancements in radiotherapy and molecularly targeted therapies have resulted in the development of potential paradigm-shifting use of radiotherapy in the treatment of cancer. In this review, we discuss some of the most promising therapeutic approaches in the field of radiation oncology. These strategies include the use of highly targeted stereotactic radiotherapy and particle therapy as well as combining radiotherapy with agents that modulate the DNA damage response, augment the immune re  ...[more]

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