Unknown

Dataset Information

0

Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial.


ABSTRACT: We previously reported the initial results of the first multicenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunotherapy (SLIT), observing a favorable safety profile associated with modest clinical and immunologic effects in the first year.We sought to provide long-term (3-year) clinical and immunologic outcomes for our peanut SLIT trial. Key end points were (1) percentage of responders at 2 years (ie, could consume 5 g of peanut powder or a 10-fold increase from baseline), (2) percentage reaching desensitization at 3 years, (3) percentage attaining sustained unresponsiveness after 3 years, (4) immunologic end points, and (5) assessment of safety parameters.Response to treatment was evaluated in 40 subjects aged 12 to 40 years by performing a 10-g peanut powder oral food challenge after 2 and 3 years of daily peanut SLIT therapy. At 3 years, SLIT was discontinued for 8 weeks, followed by another 10-g oral food challenge and an open feeding of peanut butter to assess sustained unresponsiveness.Approximately 98% of the 18,165 doses were tolerated without adverse reactions beyond the oropharynx, with no severe symptoms or uses of epinephrine. A high rate (>50%) discontinued therapy. By study's end, 4 (10.8%) of 37 SLIT-treated participants were fully desensitized to 10 g of peanut powder, and all 4 achieved sustained unresponsiveness. Responders at 2 years showed a significant decrease in peanut-specific basophil activation and skin prick test titration compared with nonresponders.Peanut SLIT induced a modest level of desensitization, decreased immunologic activity over 3 years in responders, and had an excellent long-term safety profile. However, most patients discontinued therapy by the end of year 3, and only 10.8% of subjects achieved sustained unresponsiveness.

SUBMITTER: Burks AW 

PROVIDER: S-EPMC4527157 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial.

Burks A Wesley AW   Wood Robert A RA   Jones Stacie M SM   Sicherer Scott H SH   Fleischer David M DM   Scurlock Amy M AM   Vickery Brian P BP   Liu Andrew H AH   Henning Alice K AK   Lindblad Robert R   Dawson Peter P   Plaut Marshall M   Sampson Hugh A HA  

The Journal of allergy and clinical immunology 20150203 5


<h4>Background</h4>We previously reported the initial results of the first multicenter, randomized, double-blind, placebo-controlled clinical trial of peanut sublingual immunotherapy (SLIT), observing a favorable safety profile associated with modest clinical and immunologic effects in the first year.<h4>Objective</h4>We sought to provide long-term (3-year) clinical and immunologic outcomes for our peanut SLIT trial. Key end points were (1) percentage of responders at 2 years (ie, could consume  ...[more]

Similar Datasets

| S-EPMC3550002 | biostudies-literature
| S-EPMC6842439 | biostudies-literature
| S-EPMC3759832 | biostudies-literature
| S-EPMC8612061 | biostudies-literature
| S-EPMC3052379 | biostudies-literature
| S-EPMC4732904 | biostudies-literature
| S-EPMC4430665 | biostudies-literature
| S-EPMC6494514 | biostudies-literature
| S-EPMC8346457 | biostudies-literature
| S-EPMC3983904 | biostudies-other