Interleukin-6 Stimulates Defective Angiogenesis.
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ABSTRACT:
SUBMITTER: Gopinathan G
PROVIDER: S-EPMC4527186 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Interleukin-6 Stimulates Defective Angiogenesis.
Gopinathan Ganga G Milagre Carla C Pearce Oliver M T OM Reynolds Louise E LE Hodivala-Dilke Kairbaan K Leinster David A DA Zhong Haihong H Hollingsworth Robert E RE Thompson Richard R Whiteford James R JR Balkwill Frances F
Cancer research 20150616 15
The cytokine IL6 has a number of tumor-promoting activities in human and experimental cancers, but its potential as an angiogenic agent has not been fully investigated. Here, we show that IL6 can directly induce vessel sprouting in the ex vivo aortic ring model, as well as endothelial cell proliferation and migration, with similar potency to VEGF. However, IL6-stimulated aortic ring vessel sprouts had defective pericyte coverage compared with VEGF-stimulated vessels. The mechanism of IL6 action ...[more]
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