Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.
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ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC4527315 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Notch signaling drives stemness and tumorigenicity of esophageal adenocarcinoma.
Wang Zhiqiang Z Da Silva Thiago G TG Jin Ke K Han Xiaoqing X Ranganathan Prathibha P Zhu Xiaoxia X Sanchez-Mejias Avencia A Bai Feng F Li Bin B Fei Dennis Liang DL Weaver Kelly K Carpio Rodrigo Vasquez-Del RV Moscowitz Anna E AE Koshenkov Vadim P VP Sanchez Lilly L Sparling Lynne L Pei Xin-Hai XH Franceschi Dido D Ribeiro Afonso A Robbins David J DJ Livingstone Alan S AS Capobianco Anthony J AJ
Cancer research 20140827 21
Esophageal adenocarcinoma ranks sixth in cancer mortality in the world and its incidence has risen dramatically in the Western population over the last decades. Data presented herein strongly suggest that Notch signaling is critical for esophageal adenocarcinoma and underlies resistance to chemotherapy. We present evidence that Notch signaling drives a cancer stem cell phenotype by regulating genes that establish stemness. Using patient-derived xenograft models, we demonstrate that inhibition of ...[more]
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