Genomics of immune response to typhoid and cholera vaccines.
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ABSTRACT:
SUBMITTER: Majumder PP
PROVIDER: S-EPMC4527387 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Genomics of immune response to typhoid and cholera vaccines.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20150601 1671
Considerable variation in antibody response (AR) was observed among recipients of an injectable typhoid vaccine and an oral cholera vaccine. We sought to find whether polymorphisms in genes of the immune system, both innate and adaptive, were associated with the observed variation in response. For both vaccines, we were able to discover and validate several polymorphisms that were significantly associated with immune response. For the typhoid vaccines, these polymorphisms were on genes that belo ...[more]
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