Ontology highlight
ABSTRACT:
SUBMITTER: Takeda YS
PROVIDER: S-EPMC4527703 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Takeda Yuji S YS Xu Qiaobing Q
PloS one 20150806 8
Exosomes deliver functional proteins and genetic materials to neighboring cells, and have potential applications for tissue regeneration. One possible mechanism of exosome-promoted tissue regeneration is through the delivery of microRNA (miRNA). In this study, we hypothesized that exosomes derived from neuronal progenitor cells contain miRNAs that promote neuronal differentiation. We treated mesenchymal stem cells (MSCs) daily with exosomes derived from PC12 cells, a neuronal cell line, for 1 we ...[more]